PHAR 315 Lecture Notes - Lecture 2: Pharmacodynamics, Receptor Antagonist, Hypersensitivity
Document Summary
Understand and define the terms: agonist: Drug, chemical, or molecule that binds to a receptor and cause action in the cell: partial agonist: Similar to a full agonist, but induce less of an effect. Graph resembles that of an agonist + irreversible antagonist: antagonist: Drug, chemical, or molecules that binds to a receptor and causes no action and also prevents the agonist from binding: competitive antagonist: Agonist and antagonist fight for the same active site. Emax= same, but need more drug to get to emax (i. e. ec50 is different): irreversible antagonist (poison): Antagonist bind to receptor and fully blocks the receptor. Emax: is lowered, ec50 is the same: ec50: Concentration required to achieve 50% of maximum effect: emax, maximum effect caused by the agonist, coupling: The transduction process of agonist binding to a receptor and inducing pharmacologic response within the cell. Understand the relation between drug concentration and response: response increases in proportion to dose.
