ANP 1107 Lecture Notes - Lecture 3: Extracellular Fluid, Parietal Cell, Stomach

• School: University of Ottawa
• Department: Anatomy and Physiology
• Course: ANP 1107
• Professor: Joanna Komorowski

Document Summary

4 main areas: cardia, fundus, body, pylorus and pyloric sphincter. 4 tunics & modified muscularis -muscularis externa: 3 layers of smooth muscle. Modified mucosa simple columnar epithelium mucosa production. 1, mucous neck cells: secret thin mucus: parietal cells: secret hcl and intrinsic factor. Inhibit gastrin(-feedback) stimulates cck secretion by ach, gastrin. Intrinsic factor for vit b12 for absorption in small intestine. Glycoprotein required: chief cells: inactive pensinogen + gastric lipase for lipid. Triglycerides -> fatty acids & monoglycerides: enteroendocrine cells(g cells): Hormones: gastrin: parietal stimulation for hcl and pyloric sphincter. Ghrelin for appetite & gastic movement stimulation-lots in stomach and somatostain. Mucosal barrier: layer of bicarbonate rich mucus-protection for gastric mucosa from auto digestion, tight junctions between epithelial cells for prevention for leak, division of stem cells for replacement of damaged cells. Both neural & hormonal mechanisms gives 3l gastric juice/day. Cephalic phase: reflex that begins by sensory receptors.