BCH 3120 Lecture 1: PHARM124 SUMMARY TABLES
2 May 2021
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Document Summary
De nitions: drug delivery system: more speci c and not always the same as dosage form, dosage form: type of preparation (solid, liquid, semi-solid) Safe and convenient way to administer accurate dose. Drug factors: physical and chemical properties: structure, crystalline form (polymorphism, particle size, stability, solubility, mechanism. Biopharm: adme (absorp, distribute, metab, elimin: passive di usion vs specialized transport, route of administration, rate, duration and onset. Therapeutic: disease and pt: systemic vs local administration, dose amount and dose regimen. Oral, sublingual (under tongue), buccal, rectal: parenteral (sterile) intrathecal: spine intraossesous: bone intra-articular: joint intrasynovial: joint- uid area sub-cutaneous: beneath skin. Local e ect: topical (epicutaneous, transdermal, otic (ear, nasal, rectal, vaginal, urethral, ophthalmic (sterile, conjunctival (sterile, drug discovery: 1-3 years, clinical trials: 2-10 years. Id potential candidate compounds and test e cacy + toxicity. Preformulation studies, adme, mechanism of action, dosage form, administration route, in vitro and in vivo tests: investigational new drug (ind) application.
