BIO 1140 Lecture Notes - Lecture 2: Membrane Transport Protein, Active Transport, Membrane Transport
14 Apr 2016
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Solving the mystery of dna"s structure: 1953 james watson and francis crick determined the molecular structure, how did they solve the structure. Line up in order to be lined up and at an appropriate distance. Hydrogen bonds hold the strands of dna together at the center. How the nucleotides are linked: phosphate group. Tied to the 5th carbon: 3rd carbon. Dna replication: must occur before mitosis. Replication requirements: unwind dna, 2 separate anti-parallel mother strand make 2 complimentary daughter strand. Helicase: protein that wraps around the two parental strands, at the fork. Ssbs: single stranded binding protein, stabilize the dna preventing the strands from reforming the double helix. Topoisomerase: prevents twisting as the dna unwinds. Primase: sets the stage, recruits dna polymerase 3. Dna polymerase iii: enzyme, joins the replication bubble, enhances stability, prevents it from stopping replication to soon, proofreading. Corrections of mismatches: nucleotide excision repair. What happens when you reach the limit: extended portion of your chromosome.
