BIO 2133 Lecture Notes - Lecture 14: Zygosity, Sister Chromatids, Telophase
22 Mar 2017
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You now have to map it: make crosses where you follow the known gene with the unknown and if the unknown is inherited many times with the other phenotype then they much be close on the chromosome. A humbling digression: alfred sturtevant, as an undergraduate student in morgan"s la(cid:271), sturtevant (cid:272)reated the first genetic maps. Constructing a linkage map: as major insight. Indicator of map distance between the genes: relative measure in percentages, map distance = # of recombinant products/total number of products. Identify parental types: calculate map distance between pairs of loci, determine map order. Testing hypothesis of independent assortment: should get a 1:1:1:1 ratio but he gets a different 1. If genes are on different chromosomes: aabb x aabb parental line, aabb offspring, this contains 2 recombinant (ab and ab, different than the parental line. Recombination: non sister had a crossing over event. Crossing over: 4 gametes produced, without the parentals you could not do the analysis.
