BIO 3153 Lecture Notes - Lecture 14: Lipid Signaling, Unsaturated Hydrocarbon, Fluid Mosaic Model

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Important that the membrane be fluid: can produce an artificial phospholipid layer without proteins, once receptors are added we can begin transporting ions. + dag: tail (dag) is what remains after ip3 is cleaved away and may activate pkc. Ip3 can go to er membrane and release calcium: left the membrane and becomes important messenger to release calcium from stores, calcium stored in the er and mitochondria, same inositol phospholipid involved in 2 cell signaling systems. 3 types of membrane proteins: integral proteins, alpha helices. Alpha helix: amino acid residues are pointing away from the backbone, they"re better off interacting with the hydrophobic environment, weak h-bonding causes a little twisting, until the h-bonding energy full forms an. B-sheet: amino acids directed up or down, help stabilize protein in hydrophobic environment. Alpha-helices and b-sheets compared: alpha-helices, secondary structure of most transmembrane proteins of the eukaryotic plasma membrane, flexible structural allows conformational changes.

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