HSS 2305 Lecture Notes - Lecture 8: Aureus, Lactam, Hydrolysis

• School: University of Ottawa
• Department: Health Sciences
• Course: HSS 2305
• Professor: Francois Cossette

Document Summary

Most antibiotics are derived form natural products produced by microorganisms. Antibiotics are grouped in major classes, they have a target, and may be subject to bacterial resistance: enzymes involved in the synthesis of the bacterial cell wall. It is analogue of the substrate of transpeptidase and also. An enzyme transpeptidase catalyses, from a certain substrate, the final cross-linking reaction that gives the cell wall its rigidity; if the reaction does not occur, a rigid cell wall fails to develop. Penicillin: irreversible inhibitor of transpeptidase: it fits into the active site of the enzyme, forming a covalent bond complex that cannot be dislodge. The transpeptidase substrate terminates in a d-alanin - d-alanin dipeptide: to become resistant to vancomycin, a bacterial cell must produce an. Figure 1. 13: conjugation in bacteria, two bacteria are exchanging gentic material: dna coming from a donor and travelling to a recipient through a pilus.