HSS 3305 Lecture Notes - Lecture 2: Benign Prostatic Hyperplasia, Precancerous Condition, Primary And Secondary Brain Injury

• School: University of Ottawa
• Department: Health Sciences
• Course: HSS 3305
• Professor: Karen Philips

Document Summary

Review cell biology: build on molecular/bell biology foundation to understand pathophysiology of disease, understanding cell biology: gene expression, proteins, homeostasis. Cell: semi-permeable membrane, contains organelles, nucleus: where genetic material (dna, rna, homeostasis: ph, volume, osmolarity, etc, cell-environment communication, cell function-tissue. Genotype, phenotype: phenotype: biological trait not secondarily acquired. If transmissible between different generations, phenotype is heritable, likely to have a genetic basis called genotype: genotype: genetic basis for a hereditary phenotype, environment-gene interactions (virus, ionizing radiation, epigenetics) Bifunctional adaptor molecule which matches mrna with amino acid rrna. Part of enzymatic complex which directs polypeptide assembly. Gene expression: pre-(cid:373)rna"s (cid:271)e(cid:272)o(cid:373)e (cid:373)rna-> mrna is translated and becomes protein, some parts of transcription occur in the nucleus, but some parts occur in the cytoplasm. If protein is in the wrong location, it may not be functional, if protein is transcription factor, it needs to end up in the nucleus.