HSS 3305 Lecture Notes - Lecture 3: Pathogen-Associated Molecular Pattern, Natural Killer Cell, Innate Immune System

• School: University of Ottawa
• Department: Health Sciences
• Course: HSS 3305
• Professor: Karen Philips

Document Summary

Body"s defe(cid:374)se mecha(cid:374)is(cid:373): non-specific: needs to have contact with a pathogen. 1. inflammatory reaction- nonspecific response to any harmful agent and includes phagocytosis of material by neutrophils and other macrophages. Inflammatory responses: phagocytes (natural killer cells, granulocytes, macrophages) 3rd line of defense (learned specific immunity: antibodies, specific lymphocytes that help cells communicate with each other (t-cells and b-cells, can have inflammation (innate) Specific: acquired immunity: immunity that develops after exposure to a specific agent (infection with pathogen, two systems compliment each other and function together. Innate immunity (rapid response: macrophages, dendritic cells, mast cells, granulocytes (basophils, eosinophil, neutrophil, natural killer cells, compliment proteins) Adaptive immunity (slow response: b cells (antibodies, t cells (cd4+ t cells and cd8+ t cells) Natural killer t cells are in both systems. Phagocytes: have ability to phagocytise material (ingest particles, like rumba: zooms around and sucks up everything it runs into (nonspecific) Include polynuclear leukocytes (neutrophils and eosinophils (weakly) and macrophages.