BIO152H5 Lecture Notes - Lecture 5: Metaphase, Sister Chromatids, Homologous Chromosome

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Chromosomes: 23 types of chromosomes and 2 types of each chromosome, homologous chromosome: one from each parent, x and y are sex chromosomes, humans: 2n=46. Each chromosome replicates prior to undergoing meiosis. During meiosis, chromosome number in each cell is reduced. A full complement of chromosomes is restored during fertilization: only in gametes to produce haploid gametes, phases of meiosis 1. One chromosome of each homologous pair is distributed to a different daughter cell: phases of meiosis 2. 4 daughter cells, each haploid: meiotic errors. Nondisjunction: failure of homologous chromosomes to separate. Getting less or more homologous chromosomal pairs in a daughter cell. Embryos with other aneuploidies are spontaneously aborted before birth so we do not see them. The sex chromosome and chromosome 21 may be more prone to aneuploidy than others. Why does meiosis exist: meiosis leads to genetic variation. Pairing of homologous pairs creates different patterns. Dna exchange between maternal and paternal chromatids.

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