BIO200H5 Lecture Notes - Lecture 2: Organelle, Chemical Warfare, Morphine
Document Summary
Medical and biological study of drug action. Imhotep in ancient egypt around 2500 bc: studied the physiology & anatomy of what was going on (ex; cancer). And was first to provide non-magical explanation of disease: ebers, natural medications to treat diseases in china, india soon later. Hippocrates: father of western medicine first to perform cardiothoracic surgery. Humorism (400 bc -1858 ad): many physicians thought body had 4 fluids: blood, phlegm, yellow bile, black bile. **rudolf virchow (1821-1902) discredited humorism and brang science into medicine. Serturner : first to isolate pure state of active component of herb (morphine). Discovered by-product of textile manufacturing was rich in aromatics (flat, planar, chill structure). aka acetanide. Aspirin was synthesized in synthetically pure form by this company. Chemical warfare (ww1, ww2) spurred interest in chemists; horrible symptoms from mustard gas (hair/skin loss) were observed, but then they isolated compound from mustard gas to treat cancers when used in small dosages.
