BIO200H5 Lecture Notes - Lecture 5: Muscarinic Acetylcholine Receptor, Beta Blocker, Pindolol
Document Summary
Slide 9: agonist, the structure, binding site, or the effect or all of them together could be the same. Slide 10: we can produce the same effect another way by inducing the availability of ach by inhibiting the enzyme which is responsible for degrading ach (ace) in synaptic cleft. Inhibition of ace will increase amount of ach: the functional site will be blocked. Slide 11: bind less effectively than full agonist, won"t produce maximum response. If there is no e and i add pindolol, i will have the effect as if it is a full agonist: however, normally we have e, the presence of partial agonist will reduce the effect of e. If full agonist is administered with the partial agonist, as i increase the number of molecules of partial agonist i am getting less agonist binding to the receptor because they are competing: right image.
