BIO200H5 Lecture Notes - Lecture 11: Chlorambucil, Acetylcysteine, Paracetamol

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9 Nov 2018
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The conjugate is a really stable product, udp, udp-g, you are going to attach this functional drug, very common in the liver. Slide 20: overdose of tylenol can cause jaundice, antidote is acetylcysteine, the problem with gst is that it is not water soluble. Slide 21: this may be because of the type of enzymes involved. For the lung tissue, the drugs where there are metabolites: alveolar epithelium where gas exchange occurs. If you give a drug as an inhalation or, you are going to bypass the hepatic mechanism: very thin cells which are in direct contact with a very rich capillary bed. Slide 25: masking drug metabolism, the drug is not able to pass, the drug itself is active. In this case, i have to make sure that the promoiety is safe and: the drug itself being administered. It has to show an enhanced bioavailability: why do we need to introduce promoiety to a drug.

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