BIOB11H3 Lecture Notes - Lecture 18: Spindle Apparatus, Kinesin, Ubiquitin
Document Summary
Lecture 18: cell cycle iii: biochemical regulation of mitosis & cytokinesis. Initial movement of spindle poles away from each other by bipolar kinesin motors. Movement of chromosomes away from pole: kinesin (aka polar wind) >2 & 3 make chromosome oscillate until it reaches the center b. ) Spindle poles remain separated due to bipolar kinesin-family motors. 5. ) chromosomes stay at the center plate despite the the tubulin ux, by balanced activity of + & - end motors at the kinetochore c. ) anaphase movements. 6. ) poleward movement by depolymerase present at both + & - ends of the mt. 7. ) pole separation by tubulin addition continued activity of bipolar kinesin motors and. >dynein-like motors associated with cell cortex operate on astral microtubules. Molecules are recognized for destruction by the phosphate groups added by cdks. Destruction is mediated by either scf or apc complexes. Ubiquinated protein is destroyed by proteasome (lec 11) Promotes the destruction of g1/s cyclins, cdk inhibitors.
