BIOC14H3 Lecture Notes - Lecture 3: Snp Genotyping, Pyrosequencing, Haplotype
20 Apr 2019
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Methods in gwas: collect samples (case vs control): example: if you are interested in ivf, you must look at control centers with similar age often older individuals attempt ivf, snp genotyping: whole genome snp microarray. The whole genome snp microarray is also known as a gene chip, and it covers a large number of tag snps: These are snps that are in linkage equilibrium that get inherited in blocks: haplotype. (this means if you know the snp at one location, you can predict the snp at another location: statistical analysis, replication. Goal is to rapidly scan virus markers (snps) across the genome and find the association between genetic variation and clinical conditions. You obtain patient/ control dna (after controlling for different factors) The difference in snps from the control vs patient, are the snps associated with disease. In other words: snps more common in patient"s vs non patient are more likely to be associated with the disease.
