BIOC65H3 Lecture Notes - Lecture 9: Pancuronium Bromide, Atropine, Pyridostigmine
23 Dec 2017
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Nernst equation- calculate thermodynamic flow of ions across membranes for the big 4 ions (na, k, cl, ca) Deter(cid:373)i(cid:374)es a(cid:374) io(cid:374)"s te(cid:374)de(cid:374)(cid:272)y to (cid:374)aturally flo(cid:449) i(cid:374)/out. Allows us to calculate the precise transition point (the mv) between passive in/out across plasma membrane. Nernst potential- electrical potential across membrane at which a thermodynamic equilibrium for an ion is achieved e. g chloride (cid:272)ha(cid:374)(cid:374)els (cid:272)a(cid:374) (cid:271)e for(cid:272)ed to (cid:271)e i(cid:374) a(cid:374) ope(cid:374) state (cid:448)ia drugs; it"ll flow in/out passively. Chloride nernst potential = -90mv across normal membranes (4 inside mmol; 116 outside mmol) *note: -70mv in a normal resting potential; -96mv in a normal resting cardiac potential. *note: normal action potentials are about 1-2ms but cardiac action potentials ~100-200ms. Gamma-aminobutyric acid (gaba)- inhibitory neurotransmitter e. g when gaba released relaxation. Two classes: (both inhibitory: gabaa- targets flow of chloride ions; allows influx of cl- ions (along with na+) to inhibit ap.
