EESA10H3 Lecture Notes - Lecture 4: Thyroid, Endocrine Disruptor, Hypothyroidism
16 Jun 2016
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Endocrine disrupters: human body has endocrine glands which produce hormones (overrises, pancreas, and thyroids for example). Some chemicals which are similar in structure of hormones when in body can mimic body hormones and so they interfere and disrupt normal function of body hormones, and as a result numerous of health problems. Thus called endocrine disrupters since they disrupt normal function of hormones. In direct effect they bind to hormone receptor. Since receptor recognize hormone it will also recognize mimicking chemical and carry that. Then problems with genes and problem with dna and production with protein. In indirect effect alters how much hormone produced, how well hormones transported and hormone metabolism. Reproduction function disrupted in daughters and some of sons of mothers who took synthetic estrogen pills. Thus adults less sensitive than fetuses, supports that statement. Thyroid gland produces hormones called t1 and t2, pituitary gland producing tsh, so more of that hormone then more of t1 and t2.
