HLTB21H3 Lecture Notes - Glucose-6-Phosphate Dehydrogenase Deficiency, Camillo Golgi, Sickle-Cell Disease
Document Summary
1880 discovery of malaria parasite: something distinctive in the blood, alphonse laveran. 1886 differentiation of species: camillo golgi. 1897 discovered mosquito transmission: ronald ross won noble prizes, central america. George washington and alexander the great contracted malaria. Stories of people going into forest and never came out: all die of malaria. 1906 when construction just begin: 26,000 employees, 21,000 hospitalized for malaria. 1912: 50,000 employees, 5,600 hospitalized for malaria, reduce in 6 years. Malariae: most benign and may emerge years later (4-5) Anopheles (gambiae: dusk to dawn feeder, only females as they need blood meal to reproduce, no male malaria. Only 30-40 anopheles can transmit to human. Transplacentally (mother to child: children under 5 and pregnant mother are at risk. Shared needle use: (iv drug use or medical uses) Genetic factors (positive: sickle cell trait. Those who have sickle cell trait are less susceptible. Higher rate of sickles cell, less malaria: thalassemias and g6pd deficiency, negative duffy factor.
