NROB60H3 Lecture Notes - Lecture 7: Second Messenger System, Protein Kinase, Adenylyl Cyclase
13 Dec 2016
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Receptor agonist: bind to receptor and mimics neurotransmitter. Receptor antagonist: bind to receptor and block normal neurotransmitter function. Ach nicotinic and muscarinic subtypes of receptors: curare antagonizes nicotinic. Many receptor subtypes for many neurotransmitters: usually named for agonistic drug. Dxm is a cough suppressant: act as a hallucinogen if overdose, non-selective serotonin reuptake inhibitor, nmda receptor antagonist. In all motor neurons most common neurotransmitter in pns. Acetyl coa + choline ach (with help of chat) Chat made in soma, transported to axon terminal. Ach made in cytosol and is concentrated into vesicles using transporters. Only so much choline can be taken up rate-limiting step. Degraded via ache that is secreted into the cleft. 3 different amine neurotransmitters with a catechol group: dopamine, norepinephrine, epinephrine. Dopa d opam ine n orep inephrine. Convert dopa to dopamine via dopa decarboxylase (done in all catecholaminergic neurons. Dbh used to convert dopamine to norepinephrine: only in some catecholaminergic neurons, enzyme found in vesicles.
