PSYD35H3 Lecture Notes - Lecture 11: Antipsychotic, Dopamine Receptor D2, Dopamine Receptor
Document Summary
For at least six months: prominent psychotic symptoms are present for at least one week, psychosocial functioning is poor, if present, mood disturbance is brief (vs. psychotic symptoms) Premorbid: subtle motor, cognitive, or social impairments. Prodromal: mood symptoms, cognitive symptoms, social withdrawal, or obsessive behaviours. Full syndrome: substantial functional deterioration in self-care, work, and interpersonal relationships: perceptual disturbance: auditory hallucinations (no basis in reality, thus considered psychotic) Thus, seen as the most disabling disability. Significant abnormalities in brain structure and function. Highly heritable, but does not follow any mendelian or classical genetic distribution: there are multiple symptoms that not everyone shares, thus there are different gene expressions for schizophrenia (no hallmark genetic makeup) Misconnection syndrome: neurological tracks and connections are off in some people. Positive symptoms: an addition (to non-schizophrenics: delusions, hallucinations, thought disorder normal logical thinking is absent. Negative symptoms: an absence (from non-schizophrenics: anhedonia, withdrawn, affective blunting of emotion expression.
