BIO120H1 Lecture Notes - Lecture 11: Cell Membrane, Arrestin, Mechanistic Target Of Rapamycin
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BIO120H1 Full Course Notes
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We continue with cell communication and basically how cells communicate with each other. Recall from the last lecture we went through an overview of different receptors found in animal and plant cells. We went through the example of g protein coupled or g protein linked receptor. We will continue on with g protein linked receptors today. Now these g protein coupled receptors are often associated with trimeric g proteins. Here is a blow-up of one of these trimeric g proteins, it is made up of 3 subunits: alpha, beta and gamma. The alpha and the gamma subunits are associated with the pm through fatty acid modifications so they"re anchored in the plasma membrane to these fatty acid modifications. That is why these are called trimeric g proteins, these have gtpase activity or the alpha subunit has gtpase activity. In the inactive form, the alpha subunit is bound to gdp shown in the slide.
