BIO130H1 Lecture Notes - Lecture 16: Uniporter, Facilitated Diffusion, Tight Junction
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BIO130H1 Full Course Notes
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Bio130 lecture 16: transport proteins regulate critical cellular processes. Transport proteins work together to transfer glucose from the intestine to the. Microvilli: surface area increased even more into the bloodstream inside the lumen of the intestine cytosol of the epithelial cell extracellular fluid on the basolateral side of the epithelial cell. Take glucose from inside lumen, move into epithelial cell. Moves against concentration gradient, uses energy stored in na+ gradient to do this. Na+ gradient: higher inside lumen, lower inside cell. Glucose builds up at high concentrations inside cell. Glucose uniporters (glut2) facilitate diffusion, move from high concentration to low concentration, to basolateral side and eventually into bloodstream. Build up high concentration of na+ ions, works against glucose uniporters. Na+/k+ pump (anywhere on basolateral side) needs to move na+ out of cell and k+ in, consumes atp. 3 transport proteins working together to move glucose form lumen to bloodstream. Transcellular transport of glucose requires the asymmetric distribution of.
