BIO230H1 Lecture Notes - Lecture 8: Protein Kinase A, Cyclic Adenosine Monophosphate, Binding Protein
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BIO230H1 Full Course Notes
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Document Summary
Multiple modifications can occur on the same protein. Activated pka catalytic subunits translocate to the nucleus. Pka catalytic subunits: phosphorylate specific substrate proteins, activates target genes with camp responsive elements (cre) Activated pka phosphorylates creb (cre binding protein) Creb recruits cbp (creb binding protein) coactivator: activates transcription of target genes. Regulation of abscisic acid (aba) signaling in plants. Abscisic acid is a plant hormone (not rna, dna or protein) Plays a role in plant growth and development; regulating stomatal aperture. In the absence of aba, pp2c phosphatases inhibit snrk2 kinases: snrk2 kinases cannot activate abf transcription factors, abf transcription factors are inactive, aba-responsive gene expression is off. In the presence of aba: aba binds to aba receptor and induces a conformational change, aba receptor binds and inhibits pp2c phosphatases, snrk2 kinases activate abf transcription factors, aba-responsive gene expression is on. Protein interactions lie at the heart of most biological processes. Proteins interact with small molecules, nucleic acids and/or other proteins.
