BIO230H1 Lecture Notes - Lecture 3: Adherens Junction, Tight Junction, Intermediate Filament
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BIO230H1 Full Course Notes
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Organized into 2 main tissue categories: epithelial tissues- have minimal interaction w/ extracellular matrix, sheet-like structures, connective tissues- dispersed throughout extracellular matrix, cells dispersed in the extracellular matrix, resists stretching & doesn"t allow compression. Skin & coating of organs (any barrier between different bodily compartments) Have distinct apical & basal sides: epithelial polarity". Apical: faces organ lumen / animal surface: apical microvilli- more surface = increased absorption. Basal: faces underlying tissue / extracellular space. Cytoskeletal fibres- runs through the cells & connects the cells. Forms strong, continuous adhesion belts- critical for cell adherence critical to epithelia formation. In between the individual cells, individual cadherins reach out into cell synapse. Interacts with cadherins reaching out from other side forms cadherin cluster greater adhesive strength. Mediates adhesion through: hemophilic interactions, links to actin cytoskeleton. Same structure interacting from different sides = homo (same) C terminal bound across plasma membrane (transmembrane)
