BCH210H1 Lecture Notes - Lecture 2: X-Ray Crystallography, Myoglobin, Red
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BCH210H1 Full Course Notes
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Amino acids and pka: levels of protein structure, globular, fibrous, membrane proteins. Proposed dna forms a three-helix structure with phosphate groups packed at axis and bases going out radially. Dna structures can form 3 or 4 helices in theory, but it won"t store genetic information. It"s true that phosphate can"t stabilize the structure but it is because all phosphates will be negatively charged due to ph being 7 in the body. This will cause large shattering and it will break. Isoleucine only has carboxyl and amino group that can be affected. We know that cooh pka is around 2. 4; nh3+ pka is around 8-9. You need to know this to find out which they are talking about. D would represent the second pka of nh3+ We don"t use un-ionized one because of body ph. Cooh has pka of 2 --> deprotonated at ph = 7 (leads to coo-)
