BCH210H1 Lecture 31: Anaerobic Metabolism and Gluconeogenesis (Nov. 23, 2017)
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BCH210H1 Full Course Notes
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See last lecture for question - summary of answer is shown below. Examine how energy is made and what happens under anaerobic conditions. Outline how various substrates can be used to generate glucose in gluconeogenesis. Contrast the steps and energy requirements in gluconeogenesis vs. glycolysis. Describe the reciprocal regulation of gluconeogenesis and glycolysis. If you don"t have oxygen, the complex in the ecc will not work, causing backup of all substrates. Causes excess pyruvate due to backup of nadh, and will create lactate instead. There are other molecules that can accept, but they do not exist within mitochondria. In the absence of oxygen, oxidative phosphorylation cannot occur in the mitochondria and pyruvate is converted to lactate, replenishing nad+. Will use molecule nadh to make nad+ and pyruvate is converted. This is the side reaction that will take place in the absence of oxygen or in the shut down of the oxidative phosphorylation ecc.
