BCH210H1 Lecture Notes - Lecture 27: Enolase, Phosphoglycerate Mutase, Alanine
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5 Dec 2017
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If o2 is available, pyruvate enter mitochondria and is converted to acetyl coa: further oxidation takes place in the mitochondrial matrix and a lot more atp is made, after glycolysis pyruvate (product) will be taken to the pyruvate. Dehydrogenase complex (pdc), krebs cycle and oxidative phosphorylation. Glycolysis regulation: step 1: hexokinase can be inhibited by buildup of its product, glucose-6-phosphate, step 3: pfk-1 is inhibited by the amount of atp present, and is activated by the amount of amp or -d-fructose- 2,6-bisphosphate: step 10: pyruvate kinase is regulated by phosphorylation inactivation, all three steps involve large g are are irreversible, availability of glucose also regulates glycolysis. In the reverse it is a lyase reaction ass it is adding a double bond: the reaction prefers the reverse direction, aldolase cleaves fructose 1,6-bisphosphate into. Dhap and gap: gap continues into glycolysis, triose phosphate isomerase reaction, depletes the products, drives reaction in forward direction, glyceraldehyde-3-phosphate dehydrogenase (gapdh) reaction.
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