BCH210H1 Lecture Notes - Lecture 35: Weak Base, Bicarbonate, Hemoglobin

• School: UTSG
• Department: Biochemistry
• Course: BCH210H1
• Professor: Stavroula Andreopoulos

Document Summary

Blood ph, co2 and bicarbonate: bicarbonate is a buffering species that binds with h+ ions, creates water and carbon dioxide as products which lowers the blood ph. If levels of bicarbonate are too low in the blood can also lead to detrimental effects. In a non-diabetic person, increased blood glucose stimulates insulin release from cells. Insulin binding to cell receptors leads to increased intracellular glucose concentration, atp, glycogen, fat and protein synthesis: as blood glucose falls, insulin release stops, 4-7 mm glucose in maintained throughout the body (insulin vs. glucagon) Type i diabetes: autoimmune damage of cells lead to deficient insulin production, without insulin, cellular glucose uptake is impaired, must take insulin (injection) to tell body glucose is coming into body. Reactive glucose glycation: hba1c the non-enzymatic addition of glucose to the n-terminal valine residue of the beta chains, hemoglobin can still transport o2, used to detect diabetic individuals.