HMB322H1 Lecture Notes - Lecture 8: Dash Diet, Mediterranean Diet, Translocator Protein
Document Summary
Generalized epilepsy: convulsive (grand mal), non convulsive (petit mal), myoclonic, febrile. Partial/focal epilepsy: partial seizures with elementary/complex symptoms, secondary generalization, localized to 1 part of the brain. Anterior temporal/amygdalar: lip smacking, forced searching, blank staring, epigastric distress, respiratory irregularity. Posterior temporal: auditory, vestibular, and visual phenomena. Temporal/limbic: dysmnestic state (d j vu, j"amais vu), dream state, dissociation, fear, panic, anxiety after extended seizures, brain structures break down due to neuron death if epilepsy untreated, hippocampal cells destroyed. Mendelian (autosomal dominant): neonatal convulsions, nocturnal frontal lobe epilepsy, progressive myoclonic epilepsy, cortical malformation syndromes. Complex inheritance: synaptic function/formation, ion channels, neuronal structure/function, most epilepsies concern ion channels, treatments are not blanket. Generalized epilepsy with seizures plus gene = na+ channel (b1 and a1 subunit) Benign familial neonatal convulsions gene = k+ channel kcnq 2 and 3 autosomal dominant nocturnal frontal lobe epilepsy gene = nach receptor subunit decrease burst firing by na+ channel blockade.
