IMM250H1 Lecture Notes - Lecture 8: Mesenteric Lymph Nodes, Lamina Propria, Goblet Cell
Document Summary
Chapter 8: ensure tolerance to food antigens and microbiota + respond to pathogens, skin and mucosal surfaces - portals of entry for microbes, barriers. Mucus layer: secrete antimicrobial peptides - kill/inactivate bacteria, cilia - sweep pathogens away. Damaged epithelial cells - signals to initiate in ammatory immune response. 8. 1 anatomical and structural features of the gut and gut-associated lymphoid tissues. Stomach > small intestine (ileum: ileum made up of villi and microvilli, area between two villi - crypt - undi erentiated epithelial stem cells divide to renew lining. Paneth cells ~ production of antimicrobial peptides. Small intestine > large intestine (colon: water, vitamins, ions reabsorbed. Goblet cell: secretes mucins (glycosylated proteins, mucins packed in granules > released and transported to form mucus (polypeptide, physical barrier - prevent particles from reaching epithelium. Enterocytes: produce surface-bound mucins, cover luminal and microvilli surface, + glycoprotein layer - glycocalyx, trap bacteria in mucus layer.
