IMM250H1 Lecture : Notes taken during lecture

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redtermite204

19 Dec 2011

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T cells derive from thymus, right above heart, in btw lungs. T cells like b cells antigen specific. Diversity of t cells generated by somatic recombination. Unlike b cells huoral produce antibodies. Tcr v similar to fab fragment of ig. Constant and variable regions of light and heavy chain. Antigen binding site at most distal portion of molecule. Dimer of two different chains alpha and beta chains. Cysteine residues allow disulfide bond dimer receptor. Recognize peptide antigen which are fragments of protein. Top figure three diff epitopes ig recognize epitopes exposed at surfce of proteins, recognize two kinds of epitopes. Linear epitopes formed by continuos amino acids. Conformational epitopes distant portions of amino acids segments on protein brought together when protein folds. Tcr recognition recognize peptide drived from protein some peptide epitopes epxosed at surface, like blue . Tcr access to peptide antigen not accesible to ig, because buried in protein when protein folds.

Related Questions

Which statement about Major Histocompatibility Antigens is not true?

Select one:

a. they are found on every cell in the human body

b. there are class I and class II antigens

c. class II antigens are only found on antigen-presenting cells like macrophages

d. they are recognized by T cell receptors along with foreign epitopes

e. all of the above are true

Like T cells, B cells require multiple signals for activation. Antigen binding to the B cell antigen ______ provides one signal, while antigen-specific effector ______ provide the other signals. The requirement for multiple signals to activate either a T cell or a B cell helps to prevent ______ and dangerous activation of monocytes , including ______ ______ . Most of the proteins involved in cellâcell recognition and antigen recognition in the immune system, including ______, TCRs, and ______ proteins, as well as various co-receptors, belong to the ancient Ig superfamily. This superfamily is thought to have evolved from a primordial gene encoding a single Ig- like ______ . The mechanisms for diversifying antibodies and T cell receptors by recombining gene segments may have arisen when a ______ inserted into an exon of a gene encoding an Ig family member.

receptors (BCRs) helper T cells killer T cells
inappropriate appropriate monocytes
lymphocytes self-reactive non-self-reactive
antibodies IPR MHC
domain transposon retrovirus

tanmacaw520

Fill in the blanks in the following paragraph using words from the word bank below. Not all words will be used, and some may be used more than once.

Like T cells, B cells require multiple signals for activation. Antigen binding to the B cell antigen __________provides one signal, while antigen-specific effector ________ provide the other signals. The requirement for multiple signals to activate either a T cell or a B cell helps to prevent _______ and dangerous activation of _________ , including __________ _________. Most of the proteins involved in cellâcell recognition and antigen recognition in the immune system, including _________ , TCRs, and _______ proteins, as well as various co-receptors, belong to the ancient Ig superfamily. This superfamily is thought to have evolved from a primordial gene encoding a single Ig- like _______ . The mechanisms for diversifying antibodies and T cell receptors by recombining gene segments may have arisen when a _________ inserted into an exon of a gene encoding an Ig family member.

receptors (BCRs) helper T cells killer T cells
inappropriate appropriate monocytes
lymphocytes self-reactive non-self-reactive
antibodies IPR MHC
domain transposon retrovirus

plumsquirrel992

IMM250H1 Lecture : Notes taken during lecture

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