IMM250H1 Lecture Notes - Lecture 5: Lentivirus, T-Cell Receptor, Pyroptosis
Document Summary
Overview: humoral immunity in infected individuals neutralizaion, escape, debris, cellular immunity in infected individuals control, escape and evoluion, innate immunity includes soluble factors like trappin, slpi cellular factors include trim5a and. Apobec: furthermore, immunity can be classiied as: Controlling immunity infected but do not develop immunosuppression. Transmission immunity infected but doesn"t shed or transmit virus. Life cycle: the envelope proteins bind to cd4 and a co-receptor (ccr5 or cxcr4) this stage can be blocked using. What immune response should an hiv vaccine induce: humoral immunity. Most people make neutralizing ab to their hiv infecion but they were only good at neutralizing. There are some pros though: some ab are speciic for conserved regions and do neutralize primary viruses passive infusion of cocktail is only model of sterilizing immunity shown in pre- exposure prophylaxis (pep) Broadly neutralizing ab recently high throughput screening has ideniied these ab insight into ab and virus entropy but not useful for a therapeuic vaccine: cellular immunity.
