IMM250H1 Lecture Notes - Lecture 2: Neurodegeneration, Thymus, White Pulp
Document Summary
Imm430 programmed cell death in immune diseases. Is it good or bad that cells don"t die you need a balance too many cells dying you will get immunodeiciency; not enough cells dying, you can get cancer . Homologs to these genes menioned are also found in humans (ced3 = caspases) an increase of expression of. There are two pathways to apoptosis in mammal cells: the death receptor pathway triggered by the interacion of death receptors with their ligands like. Fasl:fas and tnf-r1:tnf: the mitochondia mediated pathway intrinsic triggered by endogenous simuli like growth factor deprivaion as well as exogenous simuli such as radiaion. Substrates include, caspases, cytoskeleton proteins, nuclear proteins, proteins involved in dna repair and cell cycle proteins. Fas interacts with fasl recruiing casp8 creaing a complex once pro-casp8 are close to eachother, they autocleave and acivate leading to the processing of downstream caspases (casp3, 6, 7) downstream it cleaves its substrates causing apoptosis.
