IMM250H1 Lecture Notes - Lecture 6: Cell C, Peripheral Tolerance, Interleukin 2

• School: UTSG
• Department: Immunology
• Course: IMM250H1
• Professor: Clemenza, Phillpot

Document Summary

Immune system must recognize and respond to internal threats: entry of an internal threat: intruder breaches natural barriers like the skin. Lecture 6 adaptive: recognition: innate and adaptive, response: innate and adaptive, return to resting: important as lots of collateral damage after active immune response. Innate and adaptive: innate and adaptive employ different complementary approaches to do the same. Innate and adaptive immunity work together: pre-existing innate immunity (intrinsic) for non-specific recognition: includes skin, mucosal barrier, saliva, ph, proteases, etc, induced innate immunity for broad recognition: includes complement activation, phagocytosis, target cell lysis, inflammation. State of inflammation important as it induces innate immunity to keep infection localized to point of entry and induces adaptive immunity. Want innate immunity as keeps pathogens from growing and spreading: induced adaptive immunity: includes b cells ( antibodies), th cells ( cytokines), tc cells ( cytolysis) No inflammation no activation of lymphocytes. Innate is fast but need time for activating adaptive immunity.