IMM340H1 Lecture Notes - Lecture 7: T-Cell Receptor, Memory T Cell, Fragment Antigen-Binding
Document Summary
The tcr is a heterodimeric protein: protein structure of this molecule was very quickly characterized, tcr has the and chains both of which are transmembrane proteins. Mhc complex: complementarity determining regions (cdr"s): amino acid sequences of extreme variability found in tcr and ig v domains. The cd3 complex and the cd4 and cd8 coreceptors. Cd3 delta chain and 1 cd3 gamma chain: within the complex the 6 chains form three pairs, one epsilon delta pair, one epsilon gamma pair. 2 zeta chains: tcr and cd3 complex together is sometimes called the tcr complex, smaller picture. Instead the associated cd3 complex mediates the transduction of the signal through its cytoplasmic tails which contain lots of itams motifs: cd3 is very important in signal transduction when a tcr is engaged by antigen. Itams -- immunoreceptor tyrosine-based activation motifs: only one of the roles.
