LMP299Y1 Lecture Notes - C5-Convertase, Fibrin Degradation Product, Complement Component 3
16 Dec 2013
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Should be able to see it at the site of inflammation. Inflammatory effects of this substance inhibited by antagonist or receptor antagonist. Prolonged inflammation can damage tissue thus short-lived. In blood if not rapidly inactivated, will not have local inflammation to keep inflammation local. Stimulate target cells to produce secondary mediators amplification of the response. Vasodilation to increase blood flow (increase delivery of mediators and leukocytes to site of tissue injury or infection) Smooth muscle cells line the smooth muscle walls . Endogenous mediators products of host released in response to the pathogen plasma derived, meaning they are inactive until cleaved. Cell derived in response to pathogen . Plasma derived mediators largely produced by liver, circulate in plasma as inactive precursor. Factor 12 important activator of all four inflammatory cascades that form the. Inactive until in contact with collagen, bm, and activated platelets this happens when there is damge to vessel wall, pathogen, some tissue injurty that exposes bm.
