LMP410H1 Lecture Notes - Lecture 5: Upper Motor Neuron, Lower Motor Neuron, Ubiquitin
31 Mar 2016
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Lecture 5 als and frontaltemporal dementia (ftd) Neurons that die in the frontal temporal lobes tend to lose memory (ftd) Majority of cases are sporadic and some are familial (<10%) Neuropathology: ubiquiinated inclusions in the motor neurons of the spinal cord stain for a protein called ubiquiin. Interesing that the incidence is 2 per 100,000 which is the same as ms. Neurophysiological markers: loss of motor neurons, degeneraion of corical spinal tracts, gliosis, presence of various types of pathological inclusions 4 speciic types . Ubiquiinated inclusions which can be skein-like (1st stage), round (2nd stage) or lewy body-like inclusions (inal stage) . Bunina bodies speciic for als but less frequent. Axonal spheroids ballooned axons we all have them but in als there is a signiicant increase. Hcis occur mainly in sod1 geneic cases and appear glasslike : suggested causes of als. Motor neurons require much more energy traveling vacuoles and stuf containing important shit can be blocked much easier .
