MGY277H1 Lecture Notes - Lecture 8: Antimicrobial Resistance, Norman Heatley, Norman Bethune
27 Mar 2017
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Document Summary
Served in second boer war and again in wwi. Died of streptococcal pneumonia/meningitis at the battlefront in france. Active in socialist/communist causes moved to chain and serve chinese army during second sino-japanese war. Prognosis for people with common disease was grim before discovery of penicillin in 1940s. Physicians could identify cause, but treatment was usually bed rest. Wwii was the 1 st conflict in history where infectious disease killed fewer soldiers than combat. 1860-1910 (infection was killing us), 1910-1960 (developed treatment) Salvarsan (paul enrlich and sahachiro hata, 1910) 1st documented as of chemical as successful antimicrobial: had arsenic and was highly toxic, could treat syphilis. Enrlich coined the terms magic bullet and chemotherapy and developed the idea of finding drugs that could specifically kill microbes but not people. Red dye prontosil (gerhard domagk,1932) used to treat streptococcal infections in animals. A chemist ay bayer, dogmagk tested several chemical dyes for ability to kill streptococci in animals.
