PCL102H1 Lecture Notes - Lecture 9: Personalized Medicine, Codevelopment, Pharmacodynamics
6 Mar 2018
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Diferent biomarkers are used for diff purposes in phase2-3. In phase 4, biomarkers help categorize people into who will likely respond well to certain drugs. There was a great su(cid:272)(cid:272)ess (cid:449)he(cid:374) they are (cid:272)o(cid:373)(cid:271)i(cid:374)ed at first. Later o(cid:374), it did(cid:374)"t i(cid:373)pro(cid:448)e the (cid:373)ortality at all. How well our drugs work in people depends on decision making. Its not so much about the action of the drug, its more about how the drug moves. Hercepti binds to the her-2 receptor, blocking the receptor, preventing the growth factor from binding to the her-2 receptor, preventing cell growth. People with score 3 would be a good candidate to administer herceptin to. 89% of us convert it into an inactive product. People with low activity are at risk of overdosing, because they (cid:449)ill keep o(cid:374) taki(cid:374)g the drug (cid:271)ut it is(cid:374)"t (cid:271)ei(cid:374)g (cid:272)o(cid:374)su(cid:373)ed as they are ingesting it. A lot of people have problems converting codeiene into morphine.
