PHC320H1 Lecture Notes - Lecture 13: Chemical Kinetics, Reaction Rate Constant, Penicillin
24 Mar 2015
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Oh groups to increase solubility in aqueous solution, chemical modifications shouldn"t compromise therapeutic purpose of the drug. Stability of the drug it is the initial screening of important physical chemical properties of the drug candidate that will determine the further steps of subsequent drug development. Drug degradation is just a chemical reaction, drug react with something and reaction produce a product that is therapeutically inactive can be studied using rules of chemical kinetics. Aa +b b + +l l p. May define rate of reaction, how fast a particular reaction is consumed or product produced. Rate= -1/a (d [a]/ dt ) =-1/b (d[b]/dt = = 1/p (d[p]/dt) There are 0 order, and first order (most prevalent type of reaction in pharmaceutical studies), and 2nd order and sometimes 3rd order. First order reactions r= -1/a d[a]/dt =k [a] Being in first order reaction is proportional to the concentration of drug. In general case for first order reaction -d[a]/dt =k[a]
