PSL301H1 Lecture Notes - Lecture 25: Ascending Limb Of Loop Of Henle, Distal Convoluted Tubule, Aquaporin 1
41
PSL301H1 Full Course Notes
Verified Note
41 documents
Document Summary
Water and the kidney: sensing changes: vasopressin, water handling and the kidney, concentrated and dilute urine, water-sodium interplay. Healthy 48 yo fell while skating, momentary loc. Inc urine (10-12l per day), inc thirst for next two weeks. Serum sodium normal 140 mmol/l --> drank enough water to not be thirsty. Water restricted for 4 hours causes no change in volume or osmolality. Abnormal, should change with dec volume and inc osmolality. Given synthetic vasopressin, leading to rapid inc in urine osmolality and dec in urine flow. Synthetic is ddavp, with rapid resolution of polyuria, polydipsia, and nocturia. Typically what you drink is what you lose. Most of the water is reabsorbed in the proximal tubule. Collecting duct regulates how much water transits to the bladder. The loop of henle also plays an important role. Typically 150 l is filtered throughout the kidney. But only excretes 1. 5 l of it (less than 1%)
