PSL301H1 Lecture 12: Lecture 12- Capillary Exchange and the Lymphatic System
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PSL301H1 Full Course Notes
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Lecture 12- capillary exchange and the lymphatic system. Exercise: increased venous return (sterling"s law increased stroke volume) Overall increase in cardiac output: decreased filling time (ie increased heart rate, increased venous return, increased contractility. Must be differently controlled b/c map changes is sustained during exercise. Theories: sympathetic activity baroreceptors think elevated pressures = normal, baroreceptor transmission blocked during exercise, chemoreceptors (via low ph- co2) signals outweigh baroreceptor signals. 1 cell layer thick (very thin capillary walls) Capillary density proportional to metabolic activity of cells. 2 types of capillaries: continuous capillaries (common, fenestrated capillaries (bone marrow, spleen, liver, intestines, kidneys) b/c different nutrients are delivered. Lined with endothelial cells: joined by cell-cell junctions. Basement membranes holds entire capillary intact: connected through the entire capillary (many cell-cell junctions) Transcytosis vesicles responsible for transport: from apical (@ blood) basolateral (@ basement membrane) Have fenestrated pores (ie fenestra: are windows for protein movement & large molecules, are leaky, the main difference b/w continuous capillaries.
