PSY290H1 Lecture Notes - Lecture 7: Action Potential, Lidocaine, Bregma
Document Summary
This device allows you to position the head in a certain orientation and adjust. Orients you and allows you to hit the target location. On the right: more details for experimental work using stereotaxic surgery in rodents. There is a brain atlas, where you flip through a chart and find coordinates for the location you want to get to. The numbers you get are all in orientation to bregma, the seams in the skull of a rodent. Radio frequency: creates heat around the electrode and the heat destroys the nearby tissue. It can shut down your voltage gated sodium channels. It numbs that area of the brain, shuts that area down. It"s reversible bc when the lidocaine wears off, that tissue is fine- meaning that animal can also serve as its own control. But the drawback is that it spreads, so it cant be just that area.
