Biochemistry 2280A Lecture Notes - Lecture 12: Acetyl-Coa, Pyruvate Dehydrogenase Complex, Pyruvate Dehydrogenase
11 Feb 2017
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Pyruvate is made in the cytosol: transported into the mitochondria. Very similar to bacteria: has a double membrane. It has its own genome small and distant from the nuclear genome. Has less than 40 genes on it. At some time, this had its own complete genome and it was free living organism. One of the steps you needed to go from prokaryote to eukaryote. There is an aqueous bridge across the lipid bilayer. But small polar molecules can easily cross doesn"t provide barrier to this. Has proteins in it though: can move things across through channels and transporters. Impermeable to small molecules: need protein to help them get across. More tight regulation of what comes in and out. Has many folds in it cristae. To increase the surface area of the inner mitochondrial membrane. Handy because this is where most of the action occurs in the.
