Biochemistry 2280A Lecture Notes - Lecture 12: Pyruvic Acid, Lipid Bilayer, Gene Expression

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rosewolf498

13 Feb 2017

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Liver will also undergo gluconeogenesis and produce glucose, for the brain. Acetyl-coa 2: fatty acids, ketone bodies and biosynthesis. As our blood glucose falls lipids will be released from body"s fatty acids storage that will be metabolized. However muscle doesn"t care for anything but itself, once glucose is in the blood, or fatty acids, it will take how much it needs. Triacylglycerol will begin to be broken down to fatty acids then to acetyl-coa (oxidative process) you can get reduced cofactors which feed into the electron transport chain which is great for making atp. Process from fatty acids to acetyl coa is called beta-oxidation. 1st we need to get fatty acids, if not from food then from triacylglycerol (3 fatty acids joined to glycerol) Enzyme called lipase will break this down into fatty acids and glycerol key point of regulation. Liver uses various starting material to make it.

Related Questions

30. In final step of the triacylglycerol biosynthesis, which of the following is added to the diacylglycerol?

A. Acetyl-CoA

B. Phosphatidic acid

C. Fatty acyl-CoA

D. Glycerol-3-P

31. The activation of long chain fatty acids requires which of the following?

A. 2 ATPs

B. 2 ATPs and Co-A

C. 2 ATP, CoA and fatty-acyl CoA

D. 2 ATPs and a fatty acid.

32. What is the metabolic pathway that does not involve succinyl-CoA?

A. Ketone bodies to acetyl CoA

B. Odd chain fatty acid oxidation

C. Even chain fatty acid oxidation

D. TCA cycle

33. In order to break down fatty acids, they are first transported into the mitochondrial matrix by conversion of the fatty acid from a covalent complex with CoA to one with:

A. Citrate.

B. Oxaloacetate.

C. Malate.

D. Carnitine.

E. Pyruvate.

34. Regarding carnitine shuttle, the enzyme translocase involves which of the following pair?

A. Fatty acyl & CoA

B. Fatty acyl-carnitine & carnitine

C. Fatty acyl CoA & carnitine

D. Fatty acyl & carnitine

35. The family of drugs that are called "statins" (e.g. lipitor) are effective at lowering plasma levels of cholesterol because they:

A. slow the rate of cholesterol uptake from plasma into the cell.

B. increase the rate of synthesis of cholesterol inside the cell.

C. inhibit the activity of a key enzyme in the cholesterol synthetic pathway.

D. prevent the synthesis of Mevalonate

16- When the body is deficient in oxaloacetate

a) acetyl CoA from the b-oxdiation pathway cannot enter the citric acid cycle

b) oxaloacetate is diverted to gluconeogenesis

c) acetyl CoA is diverted to form the ketone bodies

d) all of the above are true

e) none of the above

17- The synthesis of ketone bodies involves

a) synthesis of acetoacetyl-CoA by reversal of the thiolase reaction of fatty oxidation

b) synthesis of b-hydroxy-b-methylglutaryl-CoA (HMG-CoA)

c) cleavage of HMG-CoA to acetoacetate.

d) b-Hydroxybutyrate is produced by reduction of acetoacetate.

e) all of the above

18- Which of the statements about ketone body production is FALSE?

a) Ketone bodies are produced when there is more acetyl-CoA in the liver than can be oxidized in the citric acid cycle.

b) Ketone bodies production is not a normal process, and occurs only in diabetes or starvation

c) The ketone bodies produced in the body are the free acids and not the CoA esters.

d) When fatty acid oxidation in the liver is uncontrolled, ketone body production becomes excessive and life-threatening because these acidic compounds lower the pH of blood

e) When fatty acid oxidation

19- In which of the following ways can the 4-carbon compound acetoacetyl CoA produced in fatty acid degradation be further metabolized?

a) It can break down further to form acetyl CoA,

b) It can be converted to the ketone bodies

c) It can be used for synthesis of cholesterol and its many derivÂatives.

d) It can do all of the above

e) It can do none of the above

20- Acetyl CoA from the beta-oxidation pathway cannot enter the citric acid cycle in which of these circumstances?

a) periods of fasting

b) periods of starvation

c) diabetes

d) when the body is deficient in oxaloacetate

e) all of the above

taupemarten625

For each question,choose the ONE BEST And Give Best Explanation [No Explanation nopoints :( ]

1. Metabolismis

A. the means by whichDNA is stored.

B. the sum of all theanabolic and catabolic reactions in a cell.

C. the reactions thatbreak fuel molecules down to gain energy.

D. the reactions thatsynthesise molecules in the cell.

E. the sum of all thereactions taking place in the mitochondrial matrix.

2. The Krebscycle

A. breaks downpyruvate.

B. oxidizes two-carbonunits to produce carbon dioxide and reduced coenzymes.

C. oxidizesglycerol.

D. drives H+ out of themitochondrial matrix.

E. uses GTP rather thanATP to supply phosphate groups.

3. Which of thefollowing statements about the glycolysis pathway in the cytosol isincorrect?

A. It makes ATP.

B. It makesacetyl-CoA.

C. It interacts with thepentose phosphate pathway.

D. All but three stepsare reversible and therefore also operate in gluconeogenesis.

E. It is oxidative underaerobic conditions.

4. %u03B2oxidation

A. breaks the%u03B2-glycosidic bonds in cellulose.

B. uses acetyl-CoA,NADH, and FADH2 to produce long-chain fatty acids.

C. generates pentosesugars.

D. oxidizes fatty acidsto give acetyl-CoA, NADH, and FADH2.

E. Is part oftriacylglycerol biosynthesis.

5.Gluconeogenesis is not capable of making glucose from

A. alanine.

B. lactate.

C. glycerol.

D. palmitate.

E. 2-oxoglutarate.

6. Which of thefollowing statements is incorrect concerning photosynthesis ingreen

plants?

A. It generates ATP,NADPH, and oxygen.

B. It adds carbondioxide to a five-carbon sugar that is then cleaved to form twomolecules of

phosphoglycerate.

C. Its enzymes are foundin the mitochondria.

D. It uses light energyto drive the splitting of water.

E. Its enzymes are foundin the chloroplasts.

7. Positivefeedback is operating

A. when adenosinemonophosphate activates phosphofructokinase.

B. when cAMP activatestranscription of the lac operon.

C. when tryptophaninhibits transcription of the trp operon.

D. whenN-acyl-HSL promotes transcription of the luxoperon.

E. in all the examplesabove.

8. ATP

A. is converted to ADPas H+ enters the mitochondrial matrix.

B. is a coenzyme.

C. passes through theouter mitochondrial membrane by simple diffusion.

D. cannot be made in theabsence of oxygen.

E. concentrations fall to a low levelin resting cells.

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Biochemistry 2280A Lecture Notes - Lecture 12: Pyruvic Acid, Lipid Bilayer, Gene Expression

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