Biochemistry 2280A Lecture Notes - Lecture 12: Pyruvic Acid, Acetyl-Coa, Ketone Bodies

• School: Western University
• Department: Biochemistry
• Course: Biochemistry 2280A
• Professor: Chris Brandl

Document Summary

Fatty acids in triacyclglycerols can be degraded and oxidized to acetyl-coa. Fats are used when there is no glucose available, lipases in adipocytes degrade triacylglycerol into 3 fatty acids and a glycerol. Fatty acids is used by skeletal muscles, heart, and liver, but not the brain. Glucagon activates the hormone sensitive lipase and insulin inhibits lipase. Under low glucose condition, fats are broken down by a process called -oxidation. Someone who kickboxes until his body"s glycogen supply is depleted, muscles would get energy from gluconeogenesis by the liver to provide atp and fatty acids released by adipocytes. Glycerol from triacylglycerol enter the bloodstream and go to the liver for gluconeogenesis, glucose from the liver is transported into the bloodstream and brain (in from of ketones) Fatty acids enter the blood stream and both liver and muscles converts is to acetyl-coa and it is fed into the citric acid cycle to produce atp.