Biochemistry 2280A Lecture Notes - Lecture 18: Deoxycytidine Triphosphate, Lactam, Erwin Chargaff

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Explain the chemical structure of nucleic acid polymers, without memorizing the structures of the nitrogenous bases. Describe b-dna and the higher order structures formed by rna, and the important forces that stabilize these structures. Identify chemical and structural similarities and differences between dna and rna. Rna splicing (snrna: makes up much of ribosome (rrna) o o. 2 parts: a sugar + a nitrogenous base. Nucleoside sugar with the base, but no phosphate. Nucleotide one or more phosphates on it. 3 parts: a sugar + a nitrogenous base + a phosphate. Sugars joined via phosphodiester linkages between c3" and c5" 5" end: 5" carbon is not attached to another monosaccharide (no more nucleotides) 3" end: 3" carbon is not attached to another monosaccharide (no more nucleotides) By convention, written 5" to 3", e. g. , gatc. Two dna strands associate to form a double helix. Model-building, constrained by 3 pieces of evidence: chargaff"s rule.

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