Biochemistry 2280A Lecture Notes - Lecture 24: Aflatoxin, Oxidative Stress, Oxidative Phosphorylation
8 Aug 2016
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Biochemistry 2280 topic 24 molecular basis of cancer. Cancer can be traced back to one cell that underwent inheritable change to lose growth control. Cancer is genetic, highlighted by radiation and chemical mutagens. Susceptibility to some forms (skin, colon, breast, etc. ) can be inherited. Multiple mutations needed to cause cancer: mutations accumulate over time, therefore cancer is more prevalent in old age, also why individuals with dna repair deficiencies are more susceptible to cancer. Each stage, new mutation gained that increases growth rate or allows cell to grow in different places. Lack cell adhesion molecules that hold cells in place. Don"t respond to signals that control cell division. Not sensitive to apoptosis or cellular differentiation pathways. Have abnormal metabolism use nutrients as fuel for growth, rather than generate energy through oxidative phosphorylation. Environmental agents that cause cancer: uv radiation, cigarette smoke (causes 30% of all cancers)
