Biochemistry 2288A Lecture Notes - Lecture 34: X-Inactivation, Xist (Gene), Acetyl Group
23 Jan 2017
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Document Summary
Rna polymerase recognizes promoter region made up of nucleotide sequence (tata box) as indication of where to start. Rna polymerase req"r accessory proteins (general transcription factors) to assemble on at each promoter before polymerase can begin. Three diff types of rna polymerase ( rna poly. Subunit of rna polymerase ( sigma factor) recognizes promoter region thru each base representing unique features to outside of dna helix. Rna polymerase able to initiate transcription on its own. Coordinate expression of set of genes is through being clustered together in an operon. Most mrnas last only a few minutes b4 destroye. Promoters of bact and eukar include transcription initiation sites where rna synthesis begins. Genes have regulatory dna sequences used to switch gene on/off. For regulatory dna sequences to have an effect, sequences must be recognized by transcription regulators that bind to regulatory dna sequences to control transcription: transcription regulators bind to dna helix as dimers.
