Biology 2382B Lecture Notes - Lecture 9: Rous Sarcoma Virus, Sh2 Domain, Tyrosine Kinase
Document Summary
Have ability to kinase, then they phosphotylatethemselves (autophosphorylate) Cytoplasmic domain domain that has intrinsic rtk activities. This only activates when ligand binds and it dimerizes then it has a signal xaspase. To do this need adaptor proteins bind to receptor at phosphate it made to itself and activates molecule. Most prevalent one is ras enzyme that triggers more. If things go wrong proliferation of cell triggering changes in cell cycle - cancer. Tons of receptor kinases that have many different functions, many ligands too just talking about general principles. Tyrosine kinase activity in cytosolic domain not active unless ligand activates it. Have phosphate groups on tyrosines now (this occurs initially in lip tyrosines look like lip) Always 1st tyrosines phosphorylated (lip) then other tyrosines. Adaptor proteins have specific domains that bind to tyrosines. Ptb ability to bind phosphorylated tyrosines. Many proteins that bind to phos tyrosines have ptb. Sh2 other proteins have other domains that also bind (sh2)